Mar 20, 2020

This shows the updated (March 19) official Belgian treatment guidelines for COVID19 and comparison with treatment guidelines for France,Belgium,Switzerland,Netherlands.

Notably it shows now the addition of Azithromicyn as an addition to Chloroquine/Hydroxichloroquine (cf the controversial French study source:

It's also clearly indicated that Remdesivir is now in short supply: " At this moment very restricted availability of remdesivir (long delay for supply) and very strict criteria released by Gilead "

France is still not considering hydroxichloroquine/chloroquine at this point officially for some strange reason.

Also this line seems important : " Lopinavir/ritonavir can still be therefore considered a second choice for the moment, when hydroxychloroquine is contraindicated, but only if this treatment could be administered early in the course of the disease (within 10 days after symptoms onset). We consider this treatment as futile if administered later "

So they seem to think Lopinavir/ritonavir is futile is not administered early.

And last but not least and in line with several hackernews threads. They do seem to somewhat advice physicians to possibly switch medications of infected patients with High Blood Pressure and ACE inhibitors/ARBs to an equivalent therapy.

Mar 20, 2020

I was intrigued by the results from the recent quick french study:

I read through the paper, and it's not immediately obvious, but if you look at the two graphs at the bottom, the hydroxychloroquine is 75% effective in the first chart, but only 50% in the second one. That's because the actual test was:

Control: 16

hydroxychloroquine: 14

hydroxychloroquine + azithromycin: 6

The first chart includes all 20 people who got hydroxychloroquine - including the 6 who also got azithromycin.

My question: do we know how effective azithromycin would be on it's own? Maybe it's the wonder drug we should be focused on, which would be great since it's available everywhere.

It should go without saying these are VERY preliminary results from a small trial but it's something!

Mar 19, 2020

To those who aren't aware of it, there was a recently completed (small) clinical study of hydroxychloroquine (and in some cases HCQ plus z-pack) just completed in France. The results are here:

They're miraculous. This is a well-studied, mass-produced drug which has been around for 70 years and appears to be highly effective at treating this virus.

Mar 19, 2020

It's not anecdata. There was a small clinical study which was just completed, and showed almost miraculous success with hydroxychloroquine.

Mar 19, 2020

The sky is not falling for those who read the scientific literature and act upon it promptly:

Mar 19, 2020

What about this?